肠炎康结肠定位粘附缓释片包衣工艺研究

Objective: To establish a coating method for the Changyankang Colon-targeted sustained-release tablets，to product pH-dependent colon-specific adhesion of sustained-release tablets. Methods: The use of acrylic resin (Eudragit S100) as the main coating materials for coating formulations, coating by measuring the various in vitro under the conditions of release, the quality of the coating agents to explore the impact of factors; Resuit: Prescription for coating: Eudragit S100: TEC: talcum powder (10:1:2), preparation of solid content concentration of 5%ethanol liquid coating ，Coating weight gain of 7%. Preparation of a viable coating process, coated tablets to achieve the purpose of colon-specific release.Conclusion:Plasticizers, coating weight, speed, such as spray coating affects the quality.