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“一锅法”通过串联反应合成四环占吨酮类化合物

etracyclic Xanthone Derivatives via One-Pot Cascade Reaction

中文摘要英文摘要

本文报道了一种合成多官能团化的四环占吨酮类化合物的方法。在三乙胺催化下通过不同取代基的杂环烯酮缩胺和3-醛基色酮,在室温条件下简洁高效地"一锅法"合成具有分子结构多样性的多取代的四环占吨酮类化合物。该方法的优点是高产率、反应温和、环境友好等。这一类四环占吨酮化合物具有潜在的药物活性。因此,我们以简便快速地运用这种方法合成了四环占吨酮类化合物库,以及这种合成方法应用在药物发现的平行合成中具有很大的潜力应用价值。

procedure for the synthesis of highly functional tetracyclic xanthone derivatives is described. A concise and efficient one-pot synthesis of structurally diverse tetracyclic xanthones was constructed by treating different types of heterocyclic ketene aminals with 3-formylchromone using catalytic Et3N in acetone at room temperature. The advantages of this method include high efficiency, mild reaction conditions and environmentally benign reagents. These xanthones are promising candidates for drug discovery. Consequently, a library of diverse tetracyclic xanthones was rapidly constructed using the present protocol and this concise process presented herein has great potential to be applied to parallel synthesis in drug discovery.

林军、张倩倩、严胜骄、张怡川、余富朝

药学化学制药化学工业

四环占吨酮一锅法串联反应杂环烯酮缩胺3-醛基色酮

tetracyclic xanthoneone-potcascade reactionheterocyclic ketene aminals3-formylchromone

林军,张倩倩,严胜骄,张怡川,余富朝.“一锅法”通过串联反应合成四环占吨酮类化合物[EB/OL].(2013-05-15)[2025-08-23].http://www.paper.edu.cn/releasepaper/content/201305-238.点此复制

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