气相色谱-相对密度耦合法控制十二酸的α-氯代反应深度

lpha-chloro fatty acid is an important intermediate for synthesis of alpha- hydroxy acid, alpha- amino acid, alpha- alkyl betain and some drugs,also can be applied to rare earth metal extraction. In this paper, a new method, Gas Chromatography(GC)-Relative Density(RD) coupling method, was studied for alpha-Chloro reaction depth on-line monitoring. Set alpha-Chloro reaction of dodecanoic acid(DA) as an example, we established the relationship of alpha-chlorododecanoic acid(冄-CDA) content and relative density(RD) , measuring each compound content of alpha-Chloro reaction by GC and the corresponding RD. Only needed to measure RD, we established an simple and rapid On-line monitoring alpha-Chloro reaction method by GC-RD coupling figure.