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非特异性免疫治疗对射频消融术后肝细胞癌患者免疫功能的影响

中文摘要英文摘要

目的 探讨非特异性免疫治疗对射频消融术后肝细胞癌患者免疫功能的影响。方法 采用流式细胞仪检测分析43例肝细胞癌患者治疗前和行射频消融术并接受非特异性免疫治疗后,外周血中CD4+T细胞、CD8+T细胞、NK细胞比例以及CD4+/CD8+值。结果 行射频消融术并接受非特异性免疫治疗后患者外周血中的 CD4+T 细胞、NK 细胞比例及 CD4+/CD8+值均显著高于治疗前(P<0.05),同时治疗后患者外周血中CD8+T细胞比例显著低于治疗前(P<0.05)。结论 非特异性免疫治疗可提高射频消融后肝细胞癌患者的免疫功能。

Objective To investigate the effect of radiofrequency ablation combined sequential nonspecific immune treatment onpatient with hepatic carcinoma. Methods Before and after the radiofrequency ablation combined sequential nonspecificimmune treatment, the percentage of CD4 + T cells, CD8 + T cells and NK cells on peripheral blood were evaluated by flowcytometry. Results After the nonspecific immune treatment,the percentage of CD4 + T cells, NK cells and CD4 +/CD8 + ratiowere significantly higher than that without treatment and CD8+ was significantly decreased (P<0.05). Conclusion Non-specificimmune treatment can improve the immune function in HCC after RFA.

蒋居毅(1);刘天奇(2)

10.12074/201712.00461V1

肿瘤学临床医学基础医学

肝细胞癌射频消融免疫治疗免疫功能

蒋居毅(1);刘天奇(2).非特异性免疫治疗对射频消融术后肝细胞癌患者免疫功能的影响[EB/OL].(2017-12-07)[2025-08-16].https://chinaxiv.org/abs/201712.00461.点此复制

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