复方阿胶浆对移植性lewis肺癌组织凋亡蛋白表达影响

Objective: To observe the effects of CEJS combined with chemotherapy drugs on apoptotic proteins in lewis lung carcinoma xenografts. Methods: Tumor xenografts models were prepared and randomly divided into six groups including the control group, CTX, CEJS, high-dose CEJS joint CTX, middle-dose CEJS joint CTX and low-dose CEJS joint CTX group. Then we performed paraffin imbedding and section. The expression of Bcl-2/Bax were determined by immunohistochemistry. The average optical density were evaluated by image analysis software. Results: The expression level of Bcl-2 could be significantly down-regulated and the level of Bax could be significantly up-regulated with Bcl-2/Bax lower in every experimental group, compared with the control group（p<0.01～0.05）. Compared with the CTX group, the average optical density of Bcl-2 were obviously lower（p<0.05）in high-dose CEJS joint CTX group. The average optical density of Bax were significantly higher（p<0.05）in middle-dose CEJS joint CTX group and Bcl-2/Bax were lower（p<0.01）in high or middle-dose CEJS joint CTX group, compared with the CTX group Conclusion: CEJS could induce the cell apoptosis of lung cancer by influencing the expression of Bcl-2/Bax proteins and enhance the anti-apoptotic effect caused by chemotherapy drugs.