Validity and reliability of extrastriatal [ 11 C]raclopride binding quantification in the living human brain
Validity and reliability of extrastriatal [ 11 C]raclopride binding quantification in the living human brain
Abstract [11C]raclopride is a well established PET tracer for the quantification of dopamine 2/3 receptors (D2/3R) in the striatum. Outside of the striatum the receptor density is up to two orders of magnitude lower. In contrast to striatal binding, the characteristics of extrastriatal [11C]raclopride binding quantification has not been thoroughly described. Still, binding data for e.g., neocortex is frequently reported in the scientific literature. Here we evaluate the validity and reliability of extrastriatal [11C]raclopride binding quantification. Two sets of healthy control subjects were examined with HRRT and [11C]raclopride: i) To assess the validity of extrastriatal [11C]raclopride binding estimates, eleven subjects were examined at baseline and after dosing with quetiapine, a D2/3R antagonist. ii) To assess test-retest repeatability, nine subjects were examined twice. Non displaceable binding potential (BPND) was quantified using the simplified reference tissue model. Quetiapine dosing was associated with decrease in [11C]raclopride BPND in temporal cortex (18±17% occupancy) and thalamus (20±17%), but not in frontal cortex. Extrastriatal occupancy was lower than in putamen (51±4%). The mean absolute variation was 4-7% in the striatal regions, 17% in thalamus, and 13-59% in cortical regions. Our data indicate that [11C]raclopride PET is not a suitable tool for D2/3R binding quantification in extrastriatal regions.
Farde Lars、Svensson Jonas E、Schain Martin、Plav¨|n-Sigray Pontus、Lundberg Johan、Tiger Mikael、Halldin Christer、Nord Magdalena、Cervenka Simon
Centre for Psychiatry Research, Department of Clinical Neuroscience, Karolinska Institutet & Stockholm Health Care Services, Stockholm County Council, Karolinska University Hospital||PET Science Centre, Precision Medicine and GenomicsCentre for Psychiatry Research, Department of Clinical Neuroscience, Karolinska Institutet & Stockholm Health Care Services, Stockholm County Council, Karolinska University HospitalNeurobiology Research Unit, Copenhagen University HospitalCentre for Psychiatry Research, Department of Clinical Neuroscience, Karolinska Institutet & Stockholm Health Care Services, Stockholm County Council, Karolinska University HospitalCentre for Psychiatry Research, Department of Clinical Neuroscience, Karolinska Institutet & Stockholm Health Care Services, Stockholm County Council, Karolinska University HospitalCentre for Psychiatry Research, Department of Clinical Neuroscience, Karolinska Institutet & Stockholm Health Care Services, Stockholm County Council, Karolinska University HospitalCentre for Psychiatry Research, Department of Clinical Neuroscience, Karolinska Institutet & Stockholm Health Care Services, Stockholm County Council, Karolinska University HospitalCentre for Psychiatry Research, Department of Clinical Neuroscience, Karolinska Institutet & Stockholm Health Care Services, Stockholm County Council, Karolinska University HospitalCentre for Psychiatry Research, Department of Clinical Neuroscience, Karolinska Institutet & Stockholm Health Care Services, Stockholm County Council, Karolinska University Hospital
医学研究方法基础医学神经病学、精神病学
dopamineextrastriatalpositron emission tomographyraclopridereference region
Farde Lars,Svensson Jonas E,Schain Martin,Plav¨|n-Sigray Pontus,Lundberg Johan,Tiger Mikael,Halldin Christer,Nord Magdalena,Cervenka Simon.Validity and reliability of extrastriatal [ 11 C]raclopride binding quantification in the living human brain[EB/OL].(2025-03-28)[2025-04-26].https://www.biorxiv.org/content/10.1101/600080.点此复制
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