F3表达调控的研究进展

ctivating transcription factor 3, a member of the ATF/cyclic AMP response element-binding (ATF/CREB) family of transcription factors, is an adaptive-response gene. It senses the alteration of signals in the extra- and intracellular environment, and participates in multiple cellular processes. Studies have certified that ATF3 plays a dichotomous role in apoptosis and cell cycle, therefore, ATF3 could regulate the cell proliferation and tumor progression. Researches on the expression and regulation of ATF3, and the relationship with tumor progression will contribute to look for the new strategies in cancer therapy.