妊娠晚期系统性红斑狼疮患者外周血淋巴细胞亚群的变化
lteration of lymphocyte subsets in peripheral blood at the third trimenster of pregnancy in patients with SLE
目的：探讨妊娠晚期系统性红斑狼疮(SLE)患者外周血淋巴细胞亚群的变化及意义。方法：选取20例妊娠合并SLE患者和20例正常孕妇，采用流式细胞术检测第三孕期外周血T细胞、Th细胞、Tc细胞、B细胞、自然杀伤(NK)细胞和自然杀伤T (NKT)细胞水平，比较两组孕妇妊娠晚期外周血淋巴细胞亚群比率的变化，检验孕期SLEDAI分数与外周血淋巴细胞亚群比率的相关性。结果：与正常妊娠对照组比较，妊娠合并SLE组CD3+T细胞、CD3+CD8+Tc细胞和CD3-CD19+B细胞的比率明显升高(P＜0.05)；而CD3+CD4+Th细胞、CD3-CD16+CD56+ NK及CD3+ CD16+CD56+ NKT细胞比率差异无统计学意义(P＞0.05)。妊娠合并SLE患者孕期SLEDAI分数与外周血B淋巴细胞及NK淋巴细胞的比率具有明显的正相关性(P＜0.01)。结论：妊娠合并SLE患者存在外周血淋巴细胞亚群比例失调，孕期SLEDAI分数与B细胞及NK细胞的比率具有明显相关性。
Objective To investigate the alteration of lymphocyte subsets in peripheral blood at the third trimenster pregnancy in patients with SLE. Methods 20 pregnant women complicated with SLE and 20 healthy pregnant women at the third trimenster of pregnancy were selected. The levels of T cells, Th cells, Tc cells, B cells, NK cells and NKT cells in peripheral blood were measured by FACS. Results Comparing to the normal pregnant women, pregnancy complicated with SLE women obviously promoted the ratios of CD3+ T cells, CD3+CD8+Tc cells and CD3-CD19+B cells (P＜0.05), while the ratios of CD3+CD4+Th cells, CD3-CD16+CD56+ NK cells and CD3+CD16+CD56+ NKT cells showed no significant difference(P＞0.05). A significant positive correlation was found to exist between the SLEDAI scores and both the B cells and NK cells (P＜0.01). Conclusions The imbalanced proportion of lymphocyte subsets was detected in SLE women at the third trimester of pregancy. The SLEDAI score was obviously related with the ratio of B cells and NK cells.
贺芳、陈敦金、张慧丽、庾可宁、庄家恺
内科学妇产科学基础医学
妊娠晚期系统性红斑狼疮外周血淋巴细胞亚群SLEDAI分数
hird-trimester of pregnancySystemic lupus erythematosusSubsets of peripheral blood lymphocytesSLEDAI scores
贺芳,陈敦金,张慧丽,庾可宁,庄家恺.妊娠晚期系统性红斑狼疮患者外周血淋巴细胞亚群的变化[EB/OL].(2014-09-12)[2025-08-02].http://www.paper.edu.cn/releasepaper/content/201409-127.点此复制
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