Effective in-vitro inactivation of SARS-CoV-2 by commercially available mouthwashes
Effective in-vitro inactivation of SARS-CoV-2 by commercially available mouthwashes
ABSTRACT Infectious SARS-CoV-2 can be recovered from the oral cavities and saliva of COVID-19 patients with potential implications for disease transmission. Reducing viral load in patient saliva using antiviral mouthwashes may therefore have a role as a control measure in limiting virus spread, particularly in dental settings. Here, the efficacy of SARS-CoV-2 inactivation by seven commercially available mouthwashes with a range of active ingredients were evaluated in vitro. We demonstrate ≥4.1 to ≥5.5 log10 reduction in SARS-CoV-2 titre following a one minute treatment with commercially available mouthwashes containing 0.01-0.02% stabilised hypochlorous acid or 0.58% povidone iodine, and non-specialist mouthwashes with both alcohol-based and alcohol-free formulations designed for home use. In contrast, products containing 1.5% hydrogen peroxide or 0.2% chlorhexidine gluconate were ineffective against SARS-CoV-2 in these tests. This study contributes to the growing body of evidence surrounding virucidal efficacy of mouthwashes/oral rinses against SARS-CoV-2, and has important applications in reducing risk associated with aerosol generating procedures in dentistry and potentially for infection control more widely.
Killip Marian J、Davies Katherine、Green Nicole、Mawer Damian、Seymour David W、Nixon Peter J、Woodford Neil、Roberts Allen DG、Welch Stephen R、Buczkowski Hubert
High Containment Microbiology, National Infection Service, Public Health EnglandHigh Containment Microbiology, National Infection Service, Public Health EnglandHigh Containment Microbiology, National Infection Service, Public Health EnglandYork Hospitals NHS Foundation Trust, Wigginton RoadYork Hospitals NHS Foundation Trust, Wigginton RoadYork Hospitals NHS Foundation Trust, Wigginton RoadNational Infection Service, Public Health England, 61 Colindale AvenueHigh Containment Microbiology, National Infection Service, Public Health EnglandHigh Containment Microbiology, National Infection Service, Public Health EnglandHigh Containment Microbiology, National Infection Service, Public Health England
口腔科学医学研究方法预防医学
SARS-CoV-2COVID-19coronavirusmouthwashoral rinseinactivation.
Killip Marian J,Davies Katherine,Green Nicole,Mawer Damian,Seymour David W,Nixon Peter J,Woodford Neil,Roberts Allen DG,Welch Stephen R,Buczkowski Hubert.Effective in-vitro inactivation of SARS-CoV-2 by commercially available mouthwashes[EB/OL].(2025-03-28)[2025-05-06].https://www.biorxiv.org/content/10.1101/2020.12.02.408047.点此复制
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