Ku蛋白与肿瘤诊治的研究进展

Ku protein is a multifunctional heterodimer of eukaryotes that consists of two subunits: Ku70 and Ku80. The Ku protein plays a key role in multiple nuclear processes, e.g., DNA repair, chromosome maintenance, transcription regulation, and V(D)J recombination. Now the existence of relation between Ku protein functioning and processes that lead to transformation of normal cells into cancerous ones is determined. Ku plays an important role in the sensitivies to radiation and chemotherapy for cancer. Ku might be a new target for the treatment of lung cancer and theoretical foundation on study of proteomics of apoptotic gene in drug-resistance.