No difference in risk of hospitalisation between reported cases of the SARS-CoV-2 Delta variant and Alpha variant in Norway
No difference in risk of hospitalisation between reported cases of the SARS-CoV-2 Delta variant and Alpha variant in Norway
Abstract ObjectivesTo estimate the risk of hospitalisation among reported cases of the Delta-variant of SARS-CoV-2 compared to the Alpha variant in Norway. We also estimated the risk of hospitalisation by vaccination status. MethodsWe conducted a cohort study on laboratory-confirmed cases of SARS-CoV-2 in Norway, diagnosed between 3 May and 15 August 2021. We calculated adjusted risk ratios (aRR) with 95% confidence intervals (CIs) using multivariable binomial regression, accounting for variant, vaccination status, demographic characteristics, week of sampling and underlying comorbidities. ResultsWe included 7,977 cases of Delta and 12,078 cases of Alpha. Overall, 347 (1.7%) cases were hospitalised. The aRR of hospitalisation for Delta compared to Alpha was 0.97 (95%CI 0.76–1.23). Partially vaccinated cases had a 72% reduced risk of hospitalisation (95%CI 59%–82%), and fully vaccinated cases had a 76% reduced risk (95%CI 61%–85%), compared to unvaccinated cases. ConclusionsWe found no difference in the risk of hospitalisation for Delta cases compared to Alpha cases in Norway. Further research from a wide variety of settings is needed to better understand the association between the Delta variant and severe disease. Our results support the notion that partially and fully vaccinated persons are highly protected against hospitalisation with COVID-19. HighlightsThe SARS-CoV-2 Delta variant has dominated in Norway since July 2021There was no difference in the risk of hospitalisation for Delta cases compared to AlphaPartially and fully vaccinated cases had >70% decreased risk of hospitalisation
Hungnes Olav、Kv?le Reidar、Vold Line、B??s H?kon、Valcarcel Salamanca Beatriz、Buanes Eirik Alnes、Veneti Lamprini、Starrfelt Jostein、Nyg?rd Karin、Whittaker Robert、Bragstad Karoline、Sepp?l? Elina、Storm Margrethe Larsdatter
Department of Virology, Norwegian Institute of Public HealthDepartment of Anaesthesia and Intensive Care, Haukeland University Hospital||Department of Clinical Medicine, University of BergenDepartment of Infection Control and Preparedness, Norwegian Institute of Public HealthDepartment of Infection Control and Preparedness, Norwegian Institute of Public HealthDepartment of Method Development and Analytics, Norwegian Institute of Public HealthDepartment of Anaesthesia and Intensive Care, Haukeland University Hospital||Norwegian Intensive Care and Pandemic Registry, Haukeland University HospitalDepartment of Infection Control and Preparedness, Norwegian Institute of Public HealthDepartment of Infection Control and Preparedness, Norwegian Institute of Public HealthDepartment of Infection Control and Preparedness, Norwegian Institute of Public HealthDepartment of Infection Control and Vaccines, Norwegian Institute of Public HealthDepartment of Virology, Norwegian Institute of Public HealthDepartment of Infection Control and Vaccines, Norwegian Institute of Public HealthDepartment of Infectious Disease Registries, Norwegian Institute of Public Health
医药卫生理论医学研究方法预防医学
NorwaySARS-CoV-2hospitalisationvariants of concernDeltaAlpha
Hungnes Olav,Kv?le Reidar,Vold Line,B??s H?kon,Valcarcel Salamanca Beatriz,Buanes Eirik Alnes,Veneti Lamprini,Starrfelt Jostein,Nyg?rd Karin,Whittaker Robert,Bragstad Karoline,Sepp?l? Elina,Storm Margrethe Larsdatter.No difference in risk of hospitalisation between reported cases of the SARS-CoV-2 Delta variant and Alpha variant in Norway[EB/OL].(2025-03-28)[2025-05-09].https://www.medrxiv.org/content/10.1101/2021.09.02.21263014.点此复制
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