Serotonergic Effects on Interoception
Serotonergic Effects on Interoception
Abstract Interoception is the signaling, perception, and interpretation of internal physiological states. A causal link between serotonin and interoception was tested by a within-participant, crossover, placebo-controlled study. Forty-seven healthy human volunteers were tested on and off a 20mg oral dose of the selective serotonin reuptake inhibitor (SSRI) citalopram. For each randomly ordered session, participants made a series of judgements about the synchrony of their heartbeat to auditory tones and expressed confidence in each judgement. Citalopram enhanced insight into the likelihood that a correct interoceptive judgement occurred, driven primarily by increased confidence in correct judgements. This effect was independent of measured physiological and subjective effects of the drug and greater than a null effect on insight into exclusively exteroceptive performance on a visual task. This finding provides a foundation for considering effects of serotonin on cognition, emotion, and behavior in terms of higher order processing of interoceptive events.
Campbell-Meiklejohn Daniel、Critchley Hugo D、Holmes Clare L、Garfinkel Sarah N、Livermore James J A、Adamatzky Kristian、Moga Gyorgy
School of Psychology, University of SussexDepartment of Neuroscience, Brighton and Sussex Medical School (BSMS)||Sackler Centre for Consciousness Science, University of Sussex||Sussex Partnership NHS Foundation TrustSchool of Psychology, University of SussexSackler Centre for Consciousness Science, University of Sussex||Sussex Partnership NHS Foundation Trust||Institute of Cognitive Neuroscience, University College LondonSchool of Psychology, University of Sussex||Donders Institute for Brain, Cognition and Behavior, Radboud UniversitySchool of Psychology, University of SussexSchool of Psychology, University of Sussex
基础医学生理学神经病学、精神病学
SerotoninCitalopramInteroceptionInteroceptive AwarenessConfidenceMetacognition
Campbell-Meiklejohn Daniel,Critchley Hugo D,Holmes Clare L,Garfinkel Sarah N,Livermore James J A,Adamatzky Kristian,Moga Gyorgy.Serotonergic Effects on Interoception[EB/OL].(2025-03-28)[2025-05-09].https://www.biorxiv.org/content/10.1101/2020.08.28.262550.点此复制
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