HT对小鼠的非特异免疫功能的影响
Effect of HT on the non-specific immune function of mice
目的：研究核桃树皮提取物（HT）的抑瘤作用及对非特异性免疫的调节作用。方法：建立免疫功能低下模型，检测HT对小鼠外周血细胞的影响。建立荷瘤模型，检测HT的抑瘤率及对免疫器官系数的影响；应用鸡红细胞吞噬法测定对HT对巨噬细胞吞噬功能的影响；游泳及耐缺氧实验检测HT对机体应激能力的影响。结果：HT各剂量组有明显的抑瘤作用，高剂量组抑瘤率可达60%；可显著改善巨噬细胞吞噬功能、增强机体抗应激的能力（P＜0.05）。结论：HT能抑制肿瘤增殖并调节机体的非特异性免疫功能。
Objective: Anti-tumor and immunomodulating effects of HT were studied. Methods: HT has been given to S180-bearing mice for 10-day. Tumor inhibitory rate, spleen and thymus index were calculated; phagocytosis function of Mf was determined when using chicken RBC as immumogen; experiments of swimming and anti-no-oxygen were performed to detect mice’s anti-emergency ability. Peripheral blood cells was detected based on low immune function model. Results: HT could inhibit growth of S180 in mice and its effect is dose-dependent, tumor inhibitory rate of high dose group was 60%, HT could increase spleen and thymus index, enhance Mf phagocytosis function, Conclusion: HT had anticancer effect and could enhance the non-specific immune function of mice.
李佳、张洁雨、李岩
医药卫生理论基础医学肿瘤学
HT，免疫功能低下，荷瘤，外周血细胞，巨噬细胞
HT tumor-bearing low immune function Peripheral blood cell Mf
李佳,张洁雨,李岩.HT对小鼠的非特异免疫功能的影响[EB/OL].(2008-06-12)[2025-08-10].http://www.paper.edu.cn/releasepaper/content/200806-261.点此复制
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