非血红素铁化合物模拟脂氧合酶活性
Non-heme iron(II/III) complexes that model the reactivity of lipoxygenase
使用一个N6六齿配体ctb，我们合成了三个铁配合物FeII(ctb)](ClO4)2.EtOH (1), [FeIII(OEt)(Hctb)](ClO4)3.EtOH (2), and [FeIII(OMe)(Hctb)](ClO4)3.3MeOH.4.5H2O (3)作为脂氧合酶的模型化合物。它们的催化活性的研究表明：二价配合物1不具有活性，而三价铁烷氧化合物具有催化活性。
We have synthesized and characterized three ferrous/ferric complexes of a N6 hexadentate ligand, N,N,N′,N′-tetrakis(2-benzimidazolyl-methyl)ortho-diamine-trans-cyclohexane (ctb), [FeII(ctb)](ClO4)2EtOH (1), [FeIII(OEt)(Hctb)](ClO4)3EtOH (2), and [FeIII(OMe)(Hctb)] ¬ (ClO4)33MeOH4.5H2O (3), as the models of lipoxygenases. The lipoxygenase activities of the complexes were checked and the results indicate that ferrous complex 1 is inactive while ferric alkoxide complexes 2 and 3 show the catalytic activity.
李骥、梅伏生、吴桂玲、韩芳、欧春平、李东风、廖展如、孟祥高、曹莉
化学
脂氧合酶烷氧铁化合物催化活性
lipoxygenaseferric alkoxide complexescatalysis activity
李骥,梅伏生,吴桂玲,韩芳,欧春平,李东风,廖展如,孟祥高,曹莉.非血红素铁化合物模拟脂氧合酶活性[EB/OL].(2010-02-10)[2025-08-03].http://www.paper.edu.cn/releasepaper/content/201002-436.点此复制
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