淀粉样蛋白的降解机制与阿尔茨海默病
he mechanism of amyloid beta degradation and Alzheimer's disease
背景：β淀粉样蛋白（Aβ）的蓄积在阿尔茨海默病（AD）发病过程中发挥了关键作用。研究现状：最新脑内Aβ降解系统的研究显示，降解Aβ功能的降低可导致Aβ蓄积，与AD发病密切相关。研究用途：该文章阐述了与最重要的Aβ降解酶Neprilysin与AD发病的关系，旨在为治疗AD提供策略。
Background: The deposition of Amyloid beta (Aβ) plays an important role in the pathogenesis of Alzheimer's disease (AD). Research status: It shows that the reduction of Aβ-degrading activity could result in Aβ deposition and is also close related with the pathogenesis of AD in the recent researches in the system of Aβ-degrading. Research purpose: in this review, the relationship between neprilysin (NEP) and the pathogenesis of AD was demonstrated in order to provide the strategy for treating AD.
黄树明、张博
神经病学、精神病学基础医学生物化学
生理学阿尔茨海默病β淀粉样蛋白脑啡肽酶淀粉样蛋白降解机制
physiologyAlzheimer's diseaseamyloid betaneprilysinmechanism in the Aβ-degrading
黄树明,张博.淀粉样蛋白的降解机制与阿尔茨海默病[EB/OL].(2013-03-14)[2025-08-02].http://www.paper.edu.cn/releasepaper/content/201303-563.点此复制
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