半乳糖修饰聚己内酯的制备和表征

Surface physiochemical properties of biomaterials can not only affect cell adhesion and proliferation, But also their differentiation capacity and, ultimately, the quality of new tissue formation. Poly(ε-caprolactone) (PCL) has been intensively investigated in recent years due to its good biocompatibility and biodegradability, as well as its excellent mechanical properties and machinability. However, because of its intrinsic hydrophobic and laking of bioactive functional groups on the main chain, the interactions between cells and PCL materials were hindered, which result in a limited application as tissue engineering scaffolds. Therefore, Surface modification of PCL has now became a hot way to improve its long-term biocompatibility in tissue engineering.Using lactobionic acid (LA) and NPCL as raw material, 1-Ethyl-3-[3-dimethylaminopropyl]carbodiimide hydrochloride (EDC) and N-hydroxysulfosuccinimide (NHS) as crosslinking agent to synthesis a new galactosylated poly(ε-caprolactone) (GPCL) with pendant galactose residues. The structures of polymers were characterized by 1H NMR, FT-IR, GPC, and proved the lactobionic molecules have been successfully coupled onto NPCL. The crystallinity and thermal properties of GPCL were studied by WAXD and DSC.