Hypothyroidism does not lead to worse prognosis in COVID-19: findings from the Brazilian COVID-19 registry
Hypothyroidism does not lead to worse prognosis in COVID-19: findings from the Brazilian COVID-19 registry
Abstract BackgroundIt is not clear whether previous thyroid diseases influence the course and outcomes of COVID-19. The study aims to compare clinical characteristics and outcomes of COVID-19 patients with and without hypothyroidism. MethodsThe study is a part of a multicentric cohort of patients with confirmed COVID-19 diagnosis, including data collected from 37 hospitals. Matching for age, sex, number of comorbidities and hospital was performed to select the patients without hypothyroidism for the paired analysis. ResultsFrom 7,762 COVID-19 patients, 526 had previously diagnosed hypothyroidism (50%) and 526 were selected as matched controls. The median age was 70 (interquartile range 59.0-80.0) years-old and 68.3% were females. The prevalence of underlying comorbidities were similar between groups, except for coronary and chronic kidney diseases, that had a higher prevalence in the hypothyroidism group (9.7% vs. 5.7%, p=0.015 and 9.9% vs. 4.8%, p=0.001, respectively). At hospital presentation, patients with hypothyroidism had a lower frequency of respiratory rate > 24 breaths per minute (36.1% vs 42.0%; p=0.050) and need of mechanical ventilation (4.0% vs 7.4%; p=0.016). D-dimer levels were slightly lower in hypothyroid patients (2.3 times higher than the reference value vs 2.9 times higher; p=0.037). In-hospital management was similar between groups, but hospital length-of-stay (8 vs 9 days; p=0.029) and mechanical ventilation requirement (25.4% vs. 33.1%; p=0.006) were lower for patients with hypothyroidism. There was a trend of lower in-hospital mortality in patients with hypothyroidism (22.1% vs. 27.0%; p=0.062). ConclusionIn this large Brazilian COVID-19 Registry, patients with hypothyroidism had a lower requirement of mechanical ventilation, and showed a trend of lower in-hospital mortality. Therefore, hypothyroidism does not seem to be associated with a worse prognosis, and should not be considered among the comorbidities that indicate a risk factor for COVID-19 severity.
de Godoy Mariana Frizzo、de Oliveira Thainara Concei??o、Schwarzbold Alexandre Vargas、Pozza Roberta、de Carvalho C¨antia Alcantara、de Castro Lu¨as C¨|sar、Souza Ma¨ara Dias、Campos Roberta Xavier、Francisco Saionara Cristina、Ara¨2jo Silvia Ferreira、Oliveira Diniz Thulio Henrique、Ziegelmann Patricia Klarmann、Pereira Daniella Nunes、Gontijo Silveira Leticia Ferreira、Moreira Guimar?es Milena Maria、Polanczyk Car¨asi Anne、Ponce Daniela、Lucas Fernanda Barbosa、Anschau Fernando、Aranha Fernando Gra?a、Bartolazzi Frederico、Vianna Heloisa Reniers、Lyra Batista Joanna d?ˉArc、de Alvarenga Joice Coutinho、de Morais J¨2lia Drumond Parreiras、Carneiro Marcelo、Mereilles Guimar?es Silvana Mangeon、Vietta Giovanna Grunewald、Oliveira Talita Fischer、Marcolino Milena Soriano、de Moura Costa Andr¨| Soares、Fernandes Manenti Euler Roberto、Menezes Rochele Mosmann、Martins Costa Jamille Hem¨|trio Salles、Chatkin Jos¨| Miguel、Alvarenga Samuel Penchel、Floriani Maiara Anschau、Ruschel Karen Brasil、Severino Sampaio Nat¨￠lia da Cunha、de Souza Cabral M¨￠derson Alvares、Finger Renan Goulart、Sousa Nunes Aline Gabrielle、de Almeida Cenci Evelin Paola、Ramires Yuri Carlotto、Roesch Eliane W¨1rdig、Farace Barbara Lopes、Pinheiro L¨alian Santos、Duani Helena、Nascimento Guilherme Fagundes、Pires Magda Carvalho、Assaf Pedro Ledic、de Oliveira Neimy Ramos、Kopittke Luciane、Machado-Rugolo Juliana、Monteiro Menezes Luanna Silva、Nasi Luiz Ant?nio、Rodrigues Cimini Christiane Corr¨oa、Guimar?es Henrique Cerqueira、Camargos Bicalho Maria Aparecida、Alves Nogueira Matheus Carvalho、Ferreira Couto Luciana Siuves、Rodrigues Fernanda d?ˉAthayde、Guimar?es J¨2nior Milton Henriques
内科学临床医学基础医学
HypothyroidismCOVID-19MortalityPrognosisEpidemiology
de Godoy Mariana Frizzo,de Oliveira Thainara Concei??o,Schwarzbold Alexandre Vargas,Pozza Roberta,de Carvalho C¨antia Alcantara,de Castro Lu¨as C¨|sar,Souza Ma¨ara Dias,Campos Roberta Xavier,Francisco Saionara Cristina,Ara¨2jo Silvia Ferreira,Oliveira Diniz Thulio Henrique,Ziegelmann Patricia Klarmann,Pereira Daniella Nunes,Gontijo Silveira Leticia Ferreira,Moreira Guimar?es Milena Maria,Polanczyk Car¨asi Anne,Ponce Daniela,Lucas Fernanda Barbosa,Anschau Fernando,Aranha Fernando Gra?a,Bartolazzi Frederico,Vianna Heloisa Reniers,Lyra Batista Joanna d?ˉArc,de Alvarenga Joice Coutinho,de Morais J¨2lia Drumond Parreiras,Carneiro Marcelo,Mereilles Guimar?es Silvana Mangeon,Vietta Giovanna Grunewald,Oliveira Talita Fischer,Marcolino Milena Soriano,de Moura Costa Andr¨| Soares,Fernandes Manenti Euler Roberto,Menezes Rochele Mosmann,Martins Costa Jamille Hem¨|trio Salles,Chatkin Jos¨| Miguel,Alvarenga Samuel Penchel,Floriani Maiara Anschau,Ruschel Karen Brasil,Severino Sampaio Nat¨￠lia da Cunha,de Souza Cabral M¨￠derson Alvares,Finger Renan Goulart,Sousa Nunes Aline Gabrielle,de Almeida Cenci Evelin Paola,Ramires Yuri Carlotto,Roesch Eliane W¨1rdig,Farace Barbara Lopes,Pinheiro L¨alian Santos,Duani Helena,Nascimento Guilherme Fagundes,Pires Magda Carvalho,Assaf Pedro Ledic,de Oliveira Neimy Ramos,Kopittke Luciane,Machado-Rugolo Juliana,Monteiro Menezes Luanna Silva,Nasi Luiz Ant?nio,Rodrigues Cimini Christiane Corr¨oa,Guimar?es Henrique Cerqueira,Camargos Bicalho Maria Aparecida,Alves Nogueira Matheus Carvalho,Ferreira Couto Luciana Siuves,Rodrigues Fernanda d?ˉAthayde,Guimar?es J¨2nior Milton Henriques.Hypothyroidism does not lead to worse prognosis in COVID-19: findings from the Brazilian COVID-19 registry[EB/OL].(2025-03-28)[2025-04-29].https://www.medrxiv.org/content/10.1101/2021.11.03.21265685.点此复制
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