水溶性噻吩衍生物（3-噻吩）乙氧基丁基磺酸盐的合成

he Grignard reagent is made from the raw material 3-bromothiophene through Grignard reaction. Then the Grignard reagent reacts with ethylene oxide to generate 3-thiophene ethanol. The obtained 3-thiophene ethanol reacts with sodium hydride to form sodium salt which then reacts with 1, 4-Butane sultone, generating (3-thiophene) ethoxy butyl sulfonate (TEBS). Detect and analyze every step of the product.It was found that the Grignard yield more than 90% when the molar ratio of 3 - bromothiophene and magnesium powder is 1:1.5, the lower the temperature, the higher the 3 - thiophene ethanol yield when Grignard reagent reaction with ethylene oxide that,large amount of THF is good on the reaction,the yield of 3 - thiophene ethanol is more than 70% when 3 - bromothiophene in THF concentrations below 5mol / L.In the process of preparation TEBS,The amount of the solvent toluene is a key factor to affect the yield of TEBS.