Characterization of the SARS-CoV-2 S Protein: Biophysical, Biochemical, Structural, and Antigenic Analysis
Lai Jonathan R. 1Dieterle M. Eugenia 2Jangra Rohit K. 2Barnhill Jason 3Mengotto Amanda 4Daily Johanna P. 5Pirofski Liise-anne 5Chandran Kartik 2Garrett-Thomson Sarah C. 1Herrera Natalia G. 1Tong Karen 1Kopylov Mykhailo 6Eng Edward T. 6Yen Laura Y. 6Wirchnianski Ariel S. 7Noble Alex J. 6Almo Steven C. 1Malonis Ryan J. 1Morano Nicholas C. 1Kimmel Duncan 4Massimi Aldo B. 1Florez Catalina 8Georgiev George I. 1Celikgil Alev 1Fels J. Maximilian 2Bortz Robert H. III 2Brenowitz Michael 1Haslwanter Denise 2Lee James H. 1Laudermilch Ethan 2Bonanno Jeffrey B. 1Garforth Scott J. 1Hayes David B. 9Vergnolle Olivia1
作者信息
- 1. Department of Biochemistry, Albert Einstein College of Medicine
- 2. Department of Microbiology and Immunology, Albert Einstein College of Medicine
- 3. Department of Chemistry and Life Science, United States Military Academy at West Point
- 4. Division of Infectious Diseases, Department of Medicine, Albert Einstein College of Medicine and Montefiore Medical Center
- 5. Department of Microbiology and Immunology, Albert Einstein College of Medicine||Division of Infectious Diseases, Department of Medicine, Albert Einstein College of Medicine and Montefiore Medical Center
- 6. National Resource for Molecular Microscopy, Simons Electron Microscopy Center, New York Structural Biology Center
- 7. Department of Biochemistry, Albert Einstein College of Medicine||Department of Microbiology and Immunology, Albert Einstein College of Medicine
- 8. Department of Microbiology and Immunology, Albert Einstein College of Medicine||Department of Chemistry and Life Science, United States Military Academy at West Point
- 9. Intl Solidarity of Scientists LLC
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Key words
COVID-19/SARS-CoV-2/spike/S antigen/nucleocapsid/RBD/ACE2/CD147/reproducibility/cryo-electron microscopy/size exclusion chromatography/protein production/antigenicity assays引用本文复制引用
Lai Jonathan R.,Dieterle M. Eugenia,Jangra Rohit K.,Barnhill Jason,Mengotto Amanda,Daily Johanna P.,Pirofski Liise-anne,Chandran Kartik,Garrett-Thomson Sarah C.,Herrera Natalia G.,Tong Karen,Kopylov Mykhailo,Eng Edward T.,Yen Laura Y.,Wirchnianski Ariel S.,Noble Alex J.,Almo Steven C.,Malonis Ryan J.,Morano Nicholas C.,Kimmel Duncan,Massimi Aldo B.,Florez Catalina,Georgiev George I.,Celikgil Alev,Fels J. Maximilian,Bortz Robert H. III,Brenowitz Michael,Haslwanter Denise,Lee James H.,Laudermilch Ethan,Bonanno Jeffrey B.,Garforth Scott J.,Hayes David B.,Vergnolle Olivia.Characterization of the SARS-CoV-2 S Protein: Biophysical, Biochemical, Structural, and Antigenic Analysis[EB/OL].(2025-03-28)[2025-12-13].https://www.biorxiv.org/content/10.1101/2020.06.14.150607.学科分类
生物科学研究方法、生物科学研究技术/生物化学/生物物理学
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