Age-related changes in the upper respiratory microbiome are associated with SARS-CoV-2 susceptibility and illness severity
Age-related changes in the upper respiratory microbiome are associated with SARS-CoV-2 susceptibility and illness severity
ABSTRACT Children are less susceptible to SARS-CoV-2 and typically have milder illness courses than adults. We studied the nasopharyngeal microbiomes of 274 children, adolescents, and young adults with SARS-CoV-2 exposure using 16S rRNA gene sequencing. We find that higher abundances of Corynebacterium species are associated with SARS-CoV-2 infection and SARS-CoV-2-associated respiratory symptoms, while higher abundances of Dolosigranulum pigrum are present in SARS-CoV-2-infected individuals without respiratory symptoms. We also demonstrate that the abundances of these bacteria are strongly, and independently, associated with age, suggesting that the nasopharyngeal microbiome may be a potentially modifiable mechanism by which age influences SARS-CoV-2 susceptibility and severity. SummaryEvaluation of nasopharyngeal microbiome profiles in children, adolescents, and young adults with a SARS-CoV-2-infected close contact identified specific bacterial species that vary in abundance with age and are associated with SARS-CoV-2 susceptibility and the presence of SARS-CoV-2-associated respiratory symptoms.
Aquino Jhoanna N.、Lugo Debra J.、Turner Nicholas A.、Rotta Alexandre T.、Gurley Thaddeus C.、Kelly Matthew S.、Denny Thomas N.、Heston Sarah M.、McCumber Alexander W.、Rodriguez Javier、Pfeiffer Trevor S.、Woods Christopher W.、Hurst Jillian H.、Moody M. Anthony、Rawls John F.
Department of Pediatrics, Division of Infectious Diseases, Duke University School of MedicineDepartment of Pediatrics, Division of Infectious Diseases, Duke University School of MedicineDepartment of Medicine, Division of Infectious Diseases, Duke University School of MedicineDepartment of Pediatrics, Division of Pediatric Critical Care Medicine, Duke University School of MedicineDuke Human Vaccine Institute, Duke University School of Medicine, DurhamDepartment of Pediatrics, Division of Infectious Diseases, Duke University School of Medicine||Duke Microbiome Center, Duke University School of MedicineDuke Human Vaccine Institute, Duke University School of Medicine, DurhamDepartment of Pediatrics, Division of Infectious Diseases, Duke University School of MedicineCivil and Environmental Engineering Department, Duke UniversityChildren?ˉs Clinical Research Unit, Department of Pediatrics, Duke University School of MedicineDepartment of Pediatrics, Division of Infectious Diseases, Duke University School of MedicineDepartment of Medicine, Division of Infectious Diseases, Duke University School of Medicine||Duke Human Vaccine Institute, Duke University School of Medicine, DurhamDepartment of Pediatrics, Division of Infectious Diseases, Duke University School of Medicine||Children?ˉs Health and Discovery Institute, Department of Pediatrics, Duke University School of MedicineDepartment of Pediatrics, Division of Infectious Diseases, Duke University School of Medicine||Duke Human Vaccine Institute, Duke University School of Medicine, DurhamDepartment of Molecular Genetics and Microbiology, Duke University School of Medicine||Duke Microbiome Center, Duke University School of Medicine
医学研究方法基础医学微生物学
COVID-19communitypediatricchildrennasopharyngeal microbiomeCorynebacteriumDolosigranulum
Aquino Jhoanna N.,Lugo Debra J.,Turner Nicholas A.,Rotta Alexandre T.,Gurley Thaddeus C.,Kelly Matthew S.,Denny Thomas N.,Heston Sarah M.,McCumber Alexander W.,Rodriguez Javier,Pfeiffer Trevor S.,Woods Christopher W.,Hurst Jillian H.,Moody M. Anthony,Rawls John F..Age-related changes in the upper respiratory microbiome are associated with SARS-CoV-2 susceptibility and illness severity[EB/OL].(2025-03-28)[2025-06-16].https://www.medrxiv.org/content/10.1101/2021.03.20.21252680.点此复制
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