Remote testing of vitamin D levels across the UK MS population – a case control study
Remote testing of vitamin D levels across the UK MS population – a case control study
Abstract ObjectiveThe association between vitamin D deficiency and multiple sclerosis (MS) is well described. We set out to use remote sampling to ascertain vitamin D status and vitamin D supplementation in a cross-sectional study of people with MS across the UK. MethodsPeople with MS and matched controls were recruited from across the UK. 1768 people with MS enrolled in the study; remote sampling kits were distributed to a subgroup. Dried blood spots (DBS) were used to assess serum 25(OH)D in people with MS and controls. Results1768 MS participants completed the questionnaire; 388 MS participants and 309 controls provided biological samples. Serum 25(OH)D was higher in MS than controls (median 71nmol/L vs 49nmol/L). A higher proportion of MS participants than controls supplemented (72% vs 26%, p<0.001); people with MS supplemented at higher vD doses than controls (median 1600 vs 600 IU/day, p<0.001). People with MS who did not supplement had lower serum 25(OH)D levels than non-supplementing controls (median 38 nmol/L vs 44 nmol/L). Participants engaged well with remote sampling. ConclusionsThe UK MS population have higher serum 25(OH)D than controls, mainly as a result of vitamin D supplementation. Remote sampling is a feasible way of carrying out large studies.
Giovannoni Gavin、Jacobs Benjamin Meir、Middleton Rod、Chandran Siddharthan、Dobson Ruth、Vickaryous Nicola、MacDougall Niall John James、Jitlal Mark
Preventive Neurology Unit, Wolfson Institute of Preventive Medicine, Queen Mary University London||Blizard Institute, Queen Mary University London||Department of Neurology, Royal London Hospital, BartsHealth NHS TrustPreventive Neurology Unit, Wolfson Institute of Preventive Medicine, Queen Mary University LondonUKMS Register, Swansea University Medical SchoolCentre for Clinical Brain Sciences, UK Dementia Research Institute at Edinburgh, University of EdinburghPreventive Neurology Unit, Wolfson Institute of Preventive Medicine, Queen Mary University London||Department of Neurology, Royal London Hospital, BartsHealth NHS TrustPreventive Neurology Unit, Wolfson Institute of Preventive Medicine, Queen Mary University LondonNeurology Department, Hairmyres Hospital||Neurology Department, Institute of Neurological SciencesPreventive Neurology Unit, Wolfson Institute of Preventive Medicine, Queen Mary University London
医学研究方法神经病学、精神病学预防医学
vitamin Dmultiple sclerosissupplementationremote sampling
Giovannoni Gavin,Jacobs Benjamin Meir,Middleton Rod,Chandran Siddharthan,Dobson Ruth,Vickaryous Nicola,MacDougall Niall John James,Jitlal Mark.Remote testing of vitamin D levels across the UK MS population – a case control study[EB/OL].(2025-03-28)[2025-06-23].https://www.biorxiv.org/content/10.1101/2020.10.16.342253.点此复制
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