miR-21基因启动子区多态变异与中国人群宫颈癌发病风险的关联性研究
he association of genetic variants in the promoter of miR-21 with cervical cancer risk in a Chinese population
目的:筛选miR-21基因启动子区可能影响其表达的多态变异（SNPs），研究其与宫颈癌遗传易感性的关系。方法：以571例宫颈癌患者和657例健康女性（对照组）作为研究对象，用 TaqMan MGB (minor grove binder) 探针对候选的多态位点进行基因分型，分析不同基因型与宫颈癌发生风险的关联性及基因型与宫颈癌临床表型相关性。结果：在miR-21启动子区共筛选7个SNPs(rs1295926, rs1296280, rs1295925, rs1292061, rs1292060, rs1292037, rs13137)，关联性研究结果显示：这7个SNPs基因型在病例和对照中的分布频数没有显著统计学差异，P值均大于0.05。结论：miR-21启动子区多态变异与中国人群宫颈癌发病风险没有显著关联。
Objective: To screen the single nucleotide polymorphisms (SNPs) in the promoter region of miR-143 gene that may affect its expression, and explore their relationship with cervical cancer susceptibility. Methods: In a case-control study of 571 cases and 657 controls, the candidate SNPs were genotyping using TaqMan MGB (minor grove binder) probe. The association of different genotypes of SNPs with cervical cancer risk and clinical phenotype was analyzed. Results: There were 7 SNPs in the promoter of miR-21, i.e, rs1295926, rs1296280, rs1295925, rs1292061, rs1292060, rs1292037, and rs13137. The association results revealed that these SNPs were not significantly related to cervical cancer risk. Conclusions: The polymorphisms in the miR-21 gene promoter region were not significantly associated with cervical cancer risk.
金华、王适之
基础医学肿瘤学遗传学
流行病与卫生统计学宫颈癌miR-21多态变异
epidemiology and biostatisticscervical cancermiR-21genetic variants
金华,王适之.miR-21基因启动子区多态变异与中国人群宫颈癌发病风险的关联性研究[EB/OL].(2016-08-10)[2025-08-02].http://www.paper.edu.cn/releasepaper/content/201608-72.点此复制
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