Tau pathology in early Alzheimer’s disease disrupts selective neurophysiological networks dynamics
Tau pathology in early Alzheimer’s disease disrupts selective neurophysiological networks dynamics
Abstract The role of aggregation of misfolded Tau protein in the pathogenesis of Alzheimer’s disease is the subject of rapid biomarker development and new therapeutic strategies to slow or prevent dementia. We tested the hypothesis that Tau pathology is associated with functional organization of widespread neurophysiological networks. We used electro-magnetoencephalography (E/MEG) in combination with [18F]AV1451 PET scanning to quantify Tau-dependent network disruption. Using a graph theoretical approach to MEG connectivity, we quantified nodal measures of functional segregation, centrality and efficiency of information transfer. We correlated these metrics against the nodes’ uptake of [18F]AV1451. There were both regional- and frequency-specific effects of Tau levels on the efficiency of information transfer and network segregation in early AD. Tau correlated with temporal regional participation coefficient (in delta, theta, beta bands); and temporal lobar eigenvector centrality (in theta, alpha, beta bands), but greater eccentricity at higher frequencies (gamma). The results support the translational development of neurophysiological “signatures” as biomarkers of Alzheimer’s disease, with potential to facilitate experimental medicines studies.
Firouzian Azadeh、Quinn Andrew、Cooper Elisa、Gunn Roger、Green Gary、Henson Richard N.、Kocagoncu Ece、Deep and Frequent Phenotyping study team、Rowe James B.、Lovestone Simon、Woolrich Mark W.、Greve Andrea
Invicro LLCOxford Centre for Human Brain Activity, Wellcome Centre for Integrative Neuroimaging, University of Oxford||Department of Psychiatry, University of OxfordMRC Cognition and Brain Sciences Unit, University of CambridgeInvicro LLC||Department of Medicine, Imperial College London||Department of Engineering Science, University of OxfordDepartment of Psychology, University of YorkMRC Cognition and Brain Sciences Unit, University of Cambridge||Department of Psychiatry, University of CambridgeDepartment of Clinical Neurosciences, University of CambridgeDepartment of Clinical Neurosciences, University of Cambridge||MRC Cognition and Brain Sciences Unit, University of CambridgeDepartment of Psychiatry, University of OxfordOxford Centre for Human Brain Activity, Wellcome Centre for Integrative Neuroimaging, University of Oxford||Department of Psychiatry, University of OxfordMRC Cognition and Brain Sciences Unit, University of Cambridge
神经病学、精神病学基础医学医学研究方法
Alzheimer’s diseaseDementiaGraph theoryMEGTauPET
Firouzian Azadeh,Quinn Andrew,Cooper Elisa,Gunn Roger,Green Gary,Henson Richard N.,Kocagoncu Ece,Deep and Frequent Phenotyping study team,Rowe James B.,Lovestone Simon,Woolrich Mark W.,Greve Andrea.Tau pathology in early Alzheimer’s disease disrupts selective neurophysiological networks dynamics[EB/OL].(2025-03-28)[2025-05-04].https://www.biorxiv.org/content/10.1101/524355.点此复制
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