新型抗凝药Ⅺ因子抑制剂监测方法及逆转策略研究进展

Factor F plays a major role in thrombus amplification and an ancillary role in hemostasis. This differential contribution is expected to provide new ideas for the prevention and treatment of thrombotic diseases by targeting F as a potentially safer anticoagulation strategy. Currentlyan increasing number of F inhibitors are entering phase clinical trialsand although these inhibitors showed promising clinical potentialthe strategies for monitoring and reversing the effects of these inhibitors remain unclearwhich poses new challenges for laboratory monitoring and clinical practice. This reviewbased on the physiological function of F and F inhibitors under studysystematically explored the laboratory evidence of coagulation activity linked to these inhibitorssummarized potential methods of reversal in combination with the treatment protocols of inherited F deficiencywhich provided certain references for the development of clinical treatment protocols and reversal strategies.